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LEADING THE SCIENCE OF OUR SURFACES

Discover Akthelia's pioneering approach to tackling gastrointestinal mucositis, a key driver of treatment-associated mortality in oncology.

"Epithelial surfaces in the human body are not only a physical barrier - they are crucial in maintaining healthy relationships with our microbiome and orchestrating defences against pathogens."

Professor Gudmundur Gudmundsson

CSO & Founder

OUR THERAPEUTIC FOCUS

Gastrointestinal mucositis is a key driver of mortality during cancer and transplant therapy

Epithelial tissues serve as a critical barrier, lining both internal and external surfaces of the body, while actively contributing to the immune system through dynamic immunological functions. Many cancer therapies and stem cell transplant conditioning treatments compromise the integrity of the gut mucosa, leading to severe complications such as gastrointestinal mucositis (CIGM) which manifests as inflammation, serious infections , and elevated treatment-related mortality rates. 

Akthelia Pharmaceuticals is targeting this prevalent pathology with its innovative host-directed therapy, AKT-011, designed to prevent and treat mucosal barrier injury. With a primary focus on CIGM in oncology, the therapy also holds promise for broader applications across skin, airway, gut, oral mucosa, and urogenital system disorders, as well as systemic infections and inflammatory conditions, aiming to transform patient outcomes with a new standard of care.

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UNIQUE HOST-DIRECTED APPROACH

Therapeutic science leveraging the power of millions of years of cooperative evolution

Decades of research by our founding scientists, have led us to a powerful therapeutic approach that mimics and enhances the effects of natural metabolites released by microbiota to maintain the integrity and health of their epithelial niche.

Our candidate therapeutic molecules are designed to amplify these effects, enhancing the immune status of the epithelial surface, restoring its barrier function and rejuvenating its relationships with the surrounding biology.

OUR LATEST NEWS

PARTNERS

Our
Collaborators

Great science needs great partners and we're proud to be collaborating with so many best-in-class organisations and research institutions to drive our research and development efforts forwards.

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UNIVERSITY OF ICELAND

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KAROLINSKA INSTITUTE

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THERAINDX LIFESCIENCES

EVOTEC

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ENAMINE BIENTA

UNIVERSITY OF NORTH TEXAS

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RECIPHARM

MEWBURN ELLIS

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